- Abstract:
-
BACKGROUND and AIMS: Liver ischemia/reperfusion (I/R) injury is a frequent cause of organ dysfunction. Loss of the oxygen sensor prolyl hydroxylase domain enzyme 1 (PHD1) causes tolerance of skeletal muscle to hypoxia. We assessed whether loss or short-term silencing of PHD1 could likewise induce hypoxia tolerance in hepatocytes and protect them against hepatic I/R damage. METHODS: Hepatic ischemia was induced in mice by clamping of the portal vessels of the left lateral liver lobe; 90 minut...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1053/j.gastro.2009.09.057
-
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- Journal:
- Gastroenterology
- Volume:
- 138
- Issue:
- 3
- Pages:
- 1143-54.e1-2
- Publication date:
- 2010-03-05
- DOI:
- EISSN:
-
1528-0012
- ISSN:
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0016-5085
- URN:
-
uuid:5add41a3-f90d-49b6-9b04-eaaf51f302c4
- Source identifiers:
-
74267
- Local pid:
- pubs:74267
- Language:
- English
- Keywords:
- Copyright date:
- 2010
Journal article
Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury.
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