Journal article icon

Journal article

Loss or silencing of the PHD1 prolyl hydroxylase protects livers of mice against ischemia/reperfusion injury.

Abstract:

BACKGROUND and AIMS: Liver ischemia/reperfusion (I/R) injury is a frequent cause of organ dysfunction. Loss of the oxygen sensor prolyl hydroxylase domain enzyme 1 (PHD1) causes tolerance of skeletal muscle to hypoxia. We assessed whether loss or short-term silencing of PHD1 could likewise induce hypoxia tolerance in hepatocytes and protect them against hepatic I/R damage. METHODS: Hepatic ischemia was induced in mice by clamping of the portal vessels of the left lateral liver lobe; 90 minut...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Gastroenterology
Volume:
138
Issue:
3
Pages:
1143-54.e1-2
Publication date:
2010-03-05
DOI:
EISSN:
1528-0012
ISSN:
0016-5085
URN:
uuid:5add41a3-f90d-49b6-9b04-eaaf51f302c4
Source identifiers:
74267
Local pid:
pubs:74267

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP