Journal article

Modifying membrane morphology and interactions with DNA origami clathrin-mimic networks

Abstract:: We describe the triggered assembly of a bio-inspired DNA origami meshwork on a lipid membrane. DNA triskelia, three-armed DNA origami nanostructures inspired by the membrane-modifying protein clathrin, are bound to lipid mono- and bi-layers using cholesterol anchors. Polymerization of triskelia, triggered by the addition of DNA staples, links triskelion arms to form a mesh. Using transmission electron microscopy, we observe nanoscale local deformation of a lipid monolayer induced by triskelion polymerization that is reminiscent of the formation of clathrin-coated pits. We also show that the polymerization of triskelia bound to lipid bilayers modifies interactions between them, inhibiting the formation of a synapse between giant unilamellar vesicles and a supported lipid bilayer.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Journot, C., Ramakrishna, V., Wallace, M., & Turberfield, A. (2019). Modifying membrane morphology and interactions with DNA origami clathrin-mimic networks. ACS Nano, 13(9), 9973–9979.

MLA Style

Journot, C., et al. “Modifying Membrane Morphology and Interactions with DNA Origami Clathrin-Mimic Networks.” ACS Nano, vol. 13, no. 9, American Chemical Society, 2019, pp. 9973–79.

Chicago Style

Journot, C, V Ramakrishna, M Wallace, and A Turberfield. 2019. “Modifying Membrane Morphology and Interactions with DNA Origami Clathrin-Mimic Networks.” ACS Nano 13 (9): 9973–79.
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Files:: JournotetalVoR2019.pdf

(Preview, Version of record, pdf, 3.2MB, Terms of use)

Publisher copy:: 10.1021/acsnano.8b07734

Authors

+ Journot, C More by this author

Role:: Author

+ Ramakrishna, V More by this author

Role:: Author

+ Wallace, M More by this author

Institution:: University of Oxford
Division:: MPLS Division
Department:: Chemistry
Oxford college:: Wadham College
Role:: Author
ORCID:: 0000-0002-5692-8313

+ Turberfield, A More by this author

Institution:: University of Oxford
Division:: MPLS
Department:: Physics
Sub department:: Condensed Matter Physics
Oxford college:: Magdalen College
Role:: Author
ORCID:: 0000-0002-3876-0190

Publisher:: American Chemical Society
Journal:: ACS Nano More from this journal
Volume:: 13
Issue:: 9
Pages:: 9973-9979
Publication date:: 2019-08-20
Acceptance date:: 2019-08-16
DOI:: 10.1021/acsnano.8b07734
EISSN:: 1936-086X
ISSN:: 1936-0851
Pmid:: 31418553

Language:: English
Keywords:: clathrin-inspired nanostructure

membrane interaction

DNA origami

biomimetic

nanotechnology
Pubs id:: pubs:1046650
UUID:: uuid:5adc8345-8753-40b5-be89-1a2ef85a4d5d
Local pid:: pubs:1046650
Source identifiers:: 1046650
Deposit date:: 2019-08-21

Terms of use

Copyright holder:: American Chemical Society
Copyright date:: 2019
Notes:: © 2019 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium,
provided the author and source are cited.

Licence:: CC Attribution (CC BY)

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