Journal article
Association of short-term air pollution with risk of major adverse cardiovascular event mortality and modification effects of lifestyle in Chinese adults
- Abstract:
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Background: Previous evidence showed that ambient air pollution and cardiovascular mortality are related. However, there is a lack of evidence towards the modification effect of long-term lifestyle on the association between short-term ambient air pollution and death from cardiovascular events.
Method: A total of 14,609 death from major adverse cardiovascular events (MACE) were identified among the China Kadoorie Biobank participants from 2013 to 2018. Ambient air pollution exposure including particulate matter 2.5 (PM2.5), SO2, NO2, CO, and O3 from the same period were obtained from space-time model reconstructions based on remote sensing data. Case-crossover design and conditional logistic regression was applied to estimate the effect of short-term exposure to air pollutants on MACE mortality.
Results: We found MACE mortality was significantly associated with PM2.5 (relative percent increase 2.91% per 10 µg/m3 increase, 95% CI 1.32–4.53), NO2 (5.37% per 10 µg/m3 increase, 95% CI 1.56–9.33), SO2 (6.82% per 10 µg/m3 increase, 95% CI 2.99–10.80), and CO (2.24% per 0.1 mg/m3 increase, 95% CI 1.02–3.48). Stratified analyses indicated that drinking was associated with elevated risk of MACE mortality with NO2 and SO2 exposure; physical inactivity was associated with higher risk of death from MACE when exposed to PM2.5; and people who had balanced diet had lower risk of MACE mortality when exposed to CO and NO2.
Conclusions: The study results showed that short-term exposure to ambient PM2.5, NO2, SO2, and CO would aggravate the risk of cardiovascular mortality, yet healthy lifestyle conduct might mitigate such negative impact to some extent.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 1.6MB, Terms of use)
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- Publisher copy:
- 10.1265/ehpm.24-00340
Authors
- Funder identifier:
- https://ror.org/03x94j517
- Grant:
- MC_U137686851
- MC_UU_00017/1
- MC_UU_12026/2
- Funder identifier:
- https://ror.org/029chgv08
- Grant:
- 088158/Z/09/Z
- 104085/Z/14/Z
- 212946/Z/18/Z
- 202922/Z/16/Z
- Publisher:
- Japan Science and Technology Agency
- Journal:
- Environmental Health and Preventive Medicine More from this journal
- Volume:
- 30
- Article number:
- 38
- Publication date:
- 2025-05-13
- Acceptance date:
- 2025-03-13
- DOI:
- EISSN:
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1347-4715
- ISSN:
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1342-078X
- Pmid:
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40368811
- Language:
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English
- Keywords:
- Pubs id:
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2124250
- Local pid:
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pubs:2124250
- Deposit date:
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2025-05-21
- ARK identifier:
Terms of use
- Copyright holder:
- Xiao et al.
- Copyright date:
- 2025
- Rights statement:
- © The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
- Licence:
- CC Attribution (CC BY)
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