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Biochemical and biophysical studies of the prokaryotic proton dependent oligopeptide transporters

Abstract:

The proton dependent oligopeptide transporters (POT family) are members of the Major Facilitator Superfamily of secondary active transporter proteins. They use the transmembrane proton gradient to drive the uptake of di- and tripeptides into the cytoplasm. Members of the family are highly conserved in pro- and eukaryotic genomes, and in humans they are responsible for the oral absorption of many drug families, including β-lactam antibiotics. Recently, the crystal structures of PepTSo...

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Institution:
University of Oxford
Research group:
Newstead lab, Department of Biochemistry
Oxford college:
Linacre College
Department:
Medical Sciences Division - Biochemistry

Contributors

Role:
Supervisor
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Funding agency for:
Nicolae Solcan
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK
URN:
uuid:5ad900fb-a949-4bac-b69a-f585b44a8382
Local pid:
ora:8050

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