Effects of hypothermia for perinatal asphyxia on childhood outcomes.

Journal article

Background

In the Total Body Hypothermia for Neonatal Encephalopathy Trial (TOBY), newborns with asphyxial encephalopathy who received hypothermic therapy had improved neurologic outcomes at 18 months of age, but it is uncertain whether such therapy results in longer-term neurocognitive benef its.

Methods

We randomly assigned 325 newborns with asphyxial encephalopathy who were born at a gestational age of 36 weeks or more to receive standard care alone (control) or...

Expand abstract

Authors: Azzopardi, D; Strohm, B; Marlow, N; Brocklehurst, P; Deierl, A

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Massachusetts Medical Society
• Journal: New England Journal of Medicine
• Volume: 371
• Issue: 2
• Pages: 140-149
• Publication date: 2014-07-01
• DOI: 10.1056/nejmoa1315788
• EISSN: 1533-4406
• ISSN: 0028-4793
• Language: English
• Keywords: Hypothermia, Induced; TOBY Study Group; Infant, Newborn; Follow-Up Studies; Health Status; Child; Humans; Intelligence; Survivors; Female; Asphyxia Neonatorum; Male; Psychological Tests; Cerebral Palsy; Gestational Age; Developmental Disabilities