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The dependence on intracellular ATP concentration of ATP-sensitive K-channels and of Na,K-ATPase in intact HIT-T15 beta-cells.

Abstract:

We have studied the effects of changes of intracellular ATP concentration ([ATP]i) on the activity of ATP-sensitive K-channels (IK(ATP] and of Na,K-ATPase in intact cells of the insulin-secreting cell-line HIT-T15. Pre-exposure of HIT beta-cells to oligomycin caused a dose-dependent reduction in [ATP]i. Marked activation of IK(ATP) activity was found when ATP was lowered below 3 mM. Na,K-ATPase was progressively inhibited as ATP was lowered to 1.5 mM. These data demonstrate that changes in in...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
Journal:
FEBS letters
Volume:
257
Issue:
2
Pages:
361-364
Publication date:
1989-11-05
DOI:
EISSN:
1873-3468
ISSN:
0014-5793
URN:
uuid:5a94dfa1-20ca-4da7-b85a-267362e0723c
Source identifiers:
113375
Local pid:
pubs:113375

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