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Pharmacokinetics and safety profile of artesunate-amodiaquine co-administered with antiretroviral therapy in malaria uninfected HIV-positive Malawian adults

Abstract:

There are limited data on the pharmacokinetic and safety profiles of artesunate-amodiaquine in human immnunodeficiency virus infected (HIV+) individuals receiving antiretroviral therapy. In a two-step intensive sampling pharmacokinetic trial, we compared area under the concentration-time curve from 0 to 28 days (AUC0-28 days) of an active metabolite of amodiaquine, desethylamodiaquine, and treatment-emergent adverse events between antiretroviral therapy-naive HIV+ adults and those taking nevi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1128/aac.00412-18

Authors


Dzinjalamala, F More by this author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Tropical Medicine
Mallewa, J More by this author
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European and Developing Countries Clinical Trials Partnership More from this funder
Publisher:
American Society for Microbiology Publisher's website
Journal:
Antimicrobial Agents and Chemotherapy Journal website
Volume:
62
Issue:
7
Pages:
e00412-18
Publication date:
2018-05-14
Acceptance date:
2018-05-14
DOI:
EISSN:
1098-6596
ISSN:
0066-4804
Pubs id:
pubs:848004
URN:
uri:5a85901f-8213-49e2-9be6-0e6b01520a78
UUID:
uuid:5a85901f-8213-49e2-9be6-0e6b01520a78
Local pid:
pubs:848004
Language:
English
Keywords:

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