Control of hypothalamic orexin neurons by acid and CO2.

Journal article

Hypothalamic orexin/hypocretin neurons recently emerged as key orchestrators of brain states and adaptive behaviors. They are critical for normal stimulation of wakefulness and breathing: Orexin loss causes narcolepsy and compromises vital ventilatory adaptations. However, it is unclear how orexin neurons generate appropriate adjustments in their activity during changes in physiological circumstances. Extracellular levels of acid and CO2 are fundamental physicochemical signals controlling wak...

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Authors: Williams, R; Jensen, LT; Verkhratsky, A; Fugger, L; Burdakov, D

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 104
• Issue: 25
• Pages: 10685-10690
• Publication date: 2007-06-01
• DOI: 10.1073/pnas.0702676104
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Action Potentials; Hydrogen-Ion Concentration; Hypothalamus; Intracellular Signaling Peptides and Proteins; Animals; Mice, Transgenic; Acids; Mice; Neurons; Carbon Dioxide; Patch-Clamp Techniques; Neuropeptides