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The chemical biology of branched-chain lipid metabolism.

Abstract:

Mammalian metabolism of some lipids including 3-methyl and 2-methyl branched-chain fatty acids occurs within peroxisomes. Such lipids, including phytanic and pristanic acids, are commonly found within the human diet and may be derived from chlorophyll in plant extracts. Due to the presence of a methyl group at its beta-carbon, the well-characterised beta-oxidation pathway cannot degrade phytanic acid. Instead its alpha-methylene group is oxidatively excised to give pristanic acid, which can b...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
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Journal:
Progress in lipid research
Volume:
42
Issue:
5
Pages:
359-376
Publication date:
2003-09-05
DOI:
EISSN:
1873-2194
ISSN:
0163-7827
URN:
uuid:5a811543-124f-4bbd-953c-87fe31a04f77
Source identifiers:
32389
Local pid:
pubs:32389

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