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Mitochondrial β-amyloid in Alzheimer's disease.

Abstract:

It is well established that the intracellular accumulation of Aβ (amyloid β-peptide) is associated with AD (Alzheimer's disease) and that this accumulation is toxic to neurons. The precise mechanism by which this toxicity occurs is not well understood; however, identifying the causes of this toxicity is an essential step towards developing treatments for AD. One intracellular location where the accumulation of Aβ can have a major effect is within mitochondria, where mitochondrial proteins hav...

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Publication status:
Published

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Publisher copy:
10.1042/bst0390868

Authors


Muirhead, KE More by this author
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Journal:
Biochemical Society transactions
Volume:
39
Issue:
4
Pages:
868-873
Publication date:
2011-08-05
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
URN:
uuid:5a544b3e-c1d1-4791-bc97-df079010eab0
Source identifiers:
167535
Local pid:
pubs:167535

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