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Discrimination, reversal, and shift learning in Huntington's disease: mechanisms of impaired response selection.

Abstract:

In a series of three experiments, we investigated different aspects of response selection in early-stage clinically symptomatic Huntington's disease (HD) patients in the context of discrimination learning. A series of structurally related response selection tasks involving discrimination, reversal, and shift learning were employed. In Experiment 1, the mechanisms of our previously reported [37] finding of impaired extra-dimensional shift learning were explored. The results suggested that impa...

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Publication status:
Published

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Authors


Lawrence, AD More by this author
Sahakian, BJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
Robbins, TW More by this author
Journal:
Neuropsychologia
Volume:
37
Issue:
12
Pages:
1359-1374
Publication date:
1999-11-05
DOI:
EISSN:
1873-3514
ISSN:
0028-3932
URN:
uuid:5a4d2eea-67e7-4679-916a-6bf1bb6ddd17
Source identifiers:
223172
Local pid:
pubs:223172

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