Journal article
Risk of sudden unexplained death after use of dihydroartemisinin-piperaquine for malaria: A systematic review and Bayesian meta-analysis
- Abstract:
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Background
Dihydroartemisinin–piperaquine is an effective and well tolerated artemisinin-based combination therapy that has been assessed extensively for the prevention and treatment of malaria. Piperaquine, similar to several structurally related antimalarials currently used, can prolong cardiac ventricular repolarisation duration and the electrocardiographic QT interval, leading to concerns about its proarrhythmic potential. We aimed to assess the risk of potentially lethal iat...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 454.1KB, Terms of use)
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- Publisher copy:
- 10.1016/s1473-3099(18)30297-4
Authors
- Publisher:
- Elsevier
- Journal:
- Lancet Infectious Diseases More from this journal
- Volume:
- 18
- Issue:
- 8
- Pages:
- 913-923
- Publication date:
- 2018-06-18
- Acceptance date:
- 2018-05-04
- DOI:
- EISSN:
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1474-4457
- ISSN:
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1473-3099
- Pmid:
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29887371
- Language:
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English
- Keywords:
- Pubs id:
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pubs:857574
- UUID:
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uuid:5a262354-d97b-422f-a6dc-ca2cc7f2d2fd
- Local pid:
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pubs:857574
- Source identifiers:
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857574
- Deposit date:
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2018-06-17
Terms of use
- Copyright holder:
- World Health Organization
- Copyright date:
- 2018
- Notes:
- © 2018 World Health Organization; licensee Elsevier. This is an Open Access article published under the CC BY–NC–ND 4·0 IGO license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In any use of this article, there should be no suggestion that WHO endorses any specific organisation, products or services. The use of the WHO logo is not permitted. This notice should be preserved along with the article’s original URL. A correction to this article is available here: https://doi.org/10.1016/S1473-3099(18)30419-5
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