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Associations between falls and other serious adverse events and antihypertensive medication in individuals with dementia: An observational cohort study

Abstract:

Background: The balance of benefits and risks associated with lowering blood pressure levels in individuals with dementia remains controversial with a lack of evidence for possible harms associated with antihypertensive treatment. We examined the association between antihypertensive medication and serious adverse events in individuals with dementia compared to those without dementia. Methods and findings: This was a retrospective analysis using nationally representative UK general practice po...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pmed.1004731

Authors

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Institution:
University of Oxford
Role:
Author
ORCID:
0000-0003-4151-2806
More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Role:
Author
ORCID:
0000-0001-5360-9993
More by this author
Institution:
University of Oxford
Role:
Author
ORCID:
0000-0002-4033-0915


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Funder identifier:
https://ror.org/021tj4g88
More from this funder
Funder identifier:
https://ror.org/029chgv08


Publisher:
Public Library of Science
Journal:
PLoS Medicine More from this journal
Volume:
22
Issue:
9
Pages:
e1004731
Article number:
e1004731
Publication date:
2025-09-17
Acceptance date:
2025-08-22
DOI:
EISSN:
1549-1676
ISSN:
1549-1277


Language:
English
Pubs id:
2288809
UUID:
uuid_59f74d58-6a64-40be-afc9-0b7d0ae17c75
Local pid:
pubs:2288809
Source identifiers:
3325684
Deposit date:
2025-09-30
ARK identifier:
This ORA record was generated from metadata provided by an external service. It has not been edited by the ORA Team.

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