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Two differential binding mechanisms of FG-nucleoporins and nuclear transport receptors

Abstract:

Phenylalanine-glycine-rich nucleoporins (FG-Nups) are intrinsically disordered proteins, constituting the selective barrier of the nuclear pore complex (NPC). Previous studies showed that nuclear transport receptors (NTRs) were found to interact with FG-Nups by forming an "archetypal-fuzzy" complex through the rapid formation and breakage of interactions with many individual FG motifs. Here, we use single-molecule studies combined with atomistic simulations to show that, in sharp contrast, FG...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2018.03.022

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Role:
Author
ORCID:
0000-0001-6792-7706
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European Molecular Biology Laboratory More from this funder
Gutenberg Research College More from this funder
Center for Modelling and Simulation in the Biosciences More from this funder
Klaus Tschira Foundation More from this funder
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Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
22
Issue:
13
Pages:
3660-3671
Publication date:
2018-03-27
Acceptance date:
2018-03-06
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pubs id:
pubs:835200
URN:
uri:59e5dac8-3abc-4888-b9ce-42c9f1920aaf
UUID:
uuid:59e5dac8-3abc-4888-b9ce-42c9f1920aaf
Local pid:
pubs:835200

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