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Elevated soluble CD163 in gestational diabetes mellitus: secretion from human placenta and adipose tissue.

Abstract:

Recently soluble CD163 (sCD163), a cleaved form of the macrophage receptor CD163, was identified as a macrophage-specific risk-predictor for developing Type 2 Diabetes. Here, we investigate circulating levels of sCD163 in gestational diabetes mellitus (GDM). Furthermore, given the role of the placenta in the pathogenesis of GDM, we assessed placental contribution to sCD163 secretion. Paired maternal (venous) and umbilical vein blood samples from GDM (n = 18) and Body Mass Index (BMI) matched ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0101327

Authors


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Nuffield Department of Obstetrics and Gynaecology, University of Oxford More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
9
Issue:
7
Pages:
e101327
Chapter number:
ARTN e101327
Publication date:
2014-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:59dff256-8597-4217-b196-455852b46651
Source identifiers:
500376
Local pid:
pubs:500376

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