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Journal article

A descriptive marker gene approach to single-cell pseudotime inference

Abstract:

Motivation

Pseudotime estimation from single-cell gene expression data allows the recovery of temporal information from otherwise static profiles of individual cells. Conventional pseudotime inference methods emphasize an unsupervised transcriptome-wide approach and use retrospective analysis to evaluate the behaviour of individual genes. However, the resulting trajectories can only be understood in terms of abstract geometric structures and not in terms of interpret...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1093/bioinformatics/bty498

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Department of Physiology Anatomy and Genetics
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
ORCID:
0000-0001-7615-8523
Publisher:
Oxford University Press Publisher's website
Journal:
Bioinformatics Journal website
Volume:
35
Issue:
1
Pages:
28-35
Publication date:
2018-06-23
Acceptance date:
2018-06-20
DOI:
EISSN:
1460-2059
ISSN:
1367-4803
Pubs id:
pubs:859939
URN:
uri:59c899de-74f4-4af8-873f-50802edf22f0
UUID:
uuid:59c899de-74f4-4af8-873f-50802edf22f0
Local pid:
pubs:859939
Language:
English

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