Journal article
Inter−subject variability in human atrial action potential in sinus rhythm versus atrial fibrillation patients
- Abstract:
- Human atrial electrophysiology exhibits high inter-subject variability in both sinus rhythm (SR) and chronic atrial fibrillation (cAF) patients. Variability is however rarely investigated in experimental and theoretical electrophysiological studies, thus hampering the understanding of its underlying causes but also its implications in explaining differences in the response to disease and treatment. In our study, we aim at investigating the ability of populations of human atrial cell models to capture the inter-subject variability in action potential (AP) recorded in 363 patients both under SR and cAF conditions.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 3.7MB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0105897
Authors
- Publisher:
- Public Library of Science
- Journal:
- PLoS ONE More from this journal
- Volume:
- 9
- Issue:
- 8
- Pages:
- ARTN 105897
- Publication date:
- 2014-08-26
- Acceptance date:
- 2014-07-26
- DOI:
- EISSN:
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1932-6203
- Keywords:
- UUID:
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uuid:599557e2-0f27-4309-8f5b-4b4eac4756c2
- Local pid:
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cs:8951
- Source identifiers:
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cs:8951
- Deposit date:
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2015-03-31
Terms of use
- Copyright holder:
- Sánchez et al
- Copyright date:
- 2014
- Notes:
- Copyright: © 2014 Sánchez et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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