The genetics of NOD-like receptors in Crohn's disease.

Journal article

The first Crohn's disease (CD) susceptibility gene identified was CARD15, which is a member of the emerging NOD-like receptor (NLR) family. These function as intracellular cystosolic pattern recognition receptors (PRRs) and play a central role in the innate immune response. We studied other members of the NLR family using a gene-wide haplotype tagging approach in a well-characterised collection of 547 CD patients and 465 controls. Four single nucleotide polymorphisms (SNPs) in NLRP3 had P val...

Expand abstract

Authors: Cummings, JR; Cooney, R; Clarke, G; Beckly, J; Geremia, A

• Publication status: Published
• Journal: Tissue antigens
• Volume: 76
• Issue: 1
• Pages: 48-56
• Publication date: 2010-07-01
• DOI: 10.1111/j.1399-0039.2010.01470.x
• EISSN: 1399-0039
• ISSN: 0001-2815
• Language: English
• Keywords: Genome-Wide Association Study; Female; Adult; Genotype; Male; Phenotype; Nod Signaling Adaptor Proteins; Humans; Adolescent; Genetic Predisposition to Disease; Crohn Disease; Polymorphism, Single Nucleotide