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Total synthesis of the Fusarium toxin equisetin.

Abstract:
A short stereoselective synthesis of the Fusarium toxin equisetin, a potent inhibitor of HIV-1 integrase enzyme is described, using as the key step a stereoselective intramolecular Diels-Alder reaction of a fully conjugated E,E,E-triene with a trisubstituted gamma,delta-unsaturated beta-ketothioester.
Publication status:
Published

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Publisher copy:
10.1039/b411350k

Authors


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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Rodríguez, F More by this author
Journal:
Organic and biomolecular chemistry
Volume:
3
Issue:
2
Pages:
274-280
Publication date:
2005-01-05
DOI:
EISSN:
1477-0539
ISSN:
1477-0520
URN:
uuid:598e4883-14ad-43d4-a70c-afa3016cef1e
Source identifiers:
39363
Local pid:
pubs:39363

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