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Chemoprevention of esophageal cancer with esomeprazole and aspirin therapy: efficacy and safety in the phase III randomized factorial AspECT Trial

Abstract:
Esophageal adenocarcinoma (EA) is the sixth most common cause of global cancer death. We rely on endoscopy screening to identify and monitor patients with Barrett’s esophagus (BE) and find neoplastic lesions early enough to manage their EA. This approach has a modest effect on EA supported by low quality evidence. We evaluated the efficacy of aspirin and high dose acid suppression in preventing EA in patients with BE.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1200/JCO.2018.36.18_suppl.LBA4008

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Role:
Author


Publisher:
American Society of Clinical Oncology
Host title:
American Society of Clinical Oncology Annual Meeting (ASCO 2018)
Journal:
American Society of Clinical Oncology Annual Meeting (ASCO 2018) More from this journal
Publication date:
2018-06-07
Acceptance date:
2018-03-30
DOI:


Pubs id:
pubs:833458
UUID:
uuid:5985fce4-d77e-49c0-a32d-b242d7312718
Local pid:
pubs:833458
Source identifiers:
833458
Deposit date:
2018-04-04

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