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Journal article

A JIP3-regulated GSK3β/DCX signaling pathway restricts axon branching.

Abstract:

Axon branching plays a critical role in establishing the accurate patterning of neuronal circuits in the brain. However, the mechanisms that control axon branching remain poorly understood. Here we report that knockdown of the brain-enriched signaling protein JNK-interacting protein 3 (JIP3) triggers exuberant axon branching and self-contact in primary granule neurons of the rat cerebellar cortex. JIP3 knockdown in cerebellar slices and in postnatal rat pups in vivo leads to the formation of ...

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Publication status:
Published

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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
30
Issue:
50
Pages:
16766-16776
Publication date:
2010-12-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:594a2bba-f85b-4787-a46b-6b2ef18fa639
Source identifiers:
248007
Local pid:
pubs:248007

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