Journal article
Association of heart rate and diabetes among 0.5 million adults in the China Kadoorie biobank: Results from observational and Mendelian randomization analyses
- Abstract:
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Background and aims
Observational studies have associated resting heart rate with incident diabetes. Whether the associations are causal remains unclear. We aimed to examine the shape and strength of the associations and assessed the causal relevance of such associations in Chinese adults.Methods and results
The China Kadoorie Biobank enrolled 512,891 adults in China. Cox proportional hazard regression models was conducted to estimate hazard ratios (HRs) for the associations of resting heart rate with type 2 diabetes and total diabetes. Among 92,724 participants, 36 single-nucleotide polymorphisms (SNPs) related to resting heart rate were used to construct genetic risk score. We used Mendelian randomization analyses to make the causal inferences. During a median follow-up of 9 years, 7872 incident type 2 diabetes and 13,349 incident total diabetes were documented. After regression dilution bias adjustment, each 10 bpm higher heart rate was associated with about a 26% higher risk of type 2 diabetes (HR, 1.26 [95% CI, 1.23, 1.29]) and 23% higher risk of total diabetes (HR, 1.23 [95% CI, 1.20, 1.26]). Instrumental variable analyses showed participants at top quintile compared with those at bottom quintile had 30% higher risk for type 2 diabetes (HR, 1.30 [95% CI, 1.17, 1.43]), and 10% higher risk for total diabetes (HR, 1.10 [95% CI, 1.02, 1.20]).Conclusions
This study provides evidence that resting heart rate is an important risk factor for diabetes risk. The results suggest that novel treatment approaches targeting reduction of high heart rate for incidence of diabetes may be worth further investigation.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Accepted manuscript, pdf, 237.5KB, Terms of use)
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(Preview, Supplementary materials, pdf, 483.1KB, Terms of use)
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- Publisher copy:
- 10.1016/j.numecd.2021.04.015
Authors
- Publisher:
- Elsevier
- Journal:
- Nutrition, Metabolism and Cardiovascular Diseases More from this journal
- Volume:
- 31
- Issue:
- 8
- Pages:
- 2328-2337
- Publication date:
- 2021-04-26
- Acceptance date:
- 2021-04-16
- DOI:
- EISSN:
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1590-3729
- ISSN:
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0939-4753
- Pmid:
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34052074
- Language:
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English
- Keywords:
- Pubs id:
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1179858
- Local pid:
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pubs:1179858
- Deposit date:
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2021-06-16
- ARK identifier:
Terms of use
- Copyright holder:
- Italian Diabetes Society, Italian Society for the Study of Atherosclerosis, Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University
- Copyright date:
- 2021
- Rights statement:
- © 2021 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Elsevier at https://doi.org/10.1016/j.numecd.2021.04.015
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