Journal article icon

Journal article

Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis.

Abstract:

To identify genetic variants associated with outcome from chronic lymphocytic leukemia (CLL), we genotyped 977 nonsynonymous single nucleotide polymorphisms (nsSNPs) in 755 genes with relevance to cancer biology in 425 patients participating in a phase 3 trial comparing the efficacy of fludarabine, chlorambucil, and fludarabine with cyclophosphamide as first-line treatment. Selection of nsSNPs was biased toward those likely to be functionally deleterious. SNP genotypes were linked to individu...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Sellick, GS More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Trial Service Unit
Oscier, DG More by this author
Catovsky, D More by this author
Expand authors...
Journal:
Blood
Volume:
111
Issue:
3
Pages:
1625-1633
Publication date:
2008-02-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:590a1472-2e79-4aa3-804c-06d85ae2bf5e
Source identifiers:
66704
Local pid:
pubs:66704

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP