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Association studies on ghrelin and ghrelin receptor gene polymorphisms with obesity.

Abstract:

Ghrelin exerts a stimulatory effect on appetite and regulates energy homeostasis. Ghrelin gene variants have been shown to be associated with metabolic traits, although there is evidence suggesting linkage and association with obesity and the ghrelin receptor (GHSR). We hypothesized that these genes are good candidates for susceptibility to obesity. Direct sequencing identified 12 ghrelin single-nucleotide polymorphisms (SNPs) and 8 GHSR SNPs. The 10 common SNPs were genotyped in 1,275 obese ...

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Publication status:
Published

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Publisher copy:
10.1038/oby.2008.589

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Journal:
Obesity (Silver Spring, Md.)
Volume:
17
Issue:
4
Pages:
745-754
Publication date:
2009-04-05
DOI:
EISSN:
1930-739X
ISSN:
1930-7381
URN:
uuid:58fae5a6-a165-4f72-b41a-36934620b543
Source identifiers:
138155
Local pid:
pubs:138155

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