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Journal article

The increase in pulmonary arterial pressure caused by hypoxia depends on iron status.

Abstract:

Hypoxia is a major cause of pulmonary hypertension. Gene expression activated by the transcription factor hypoxia-inducible factor (HIF) is central to this process. The oxygen-sensing iron-dependent dioxygenase enzymes that regulate HIF are highly sensitive to varying iron availability. It is unknown whether iron similarly influences the pulmonary vasculature. This human physiology study aimed to determine whether varying iron availability affects pulmonary arterial pressure and the pulmonary...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
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Journal:
Journal of physiology
Volume:
586
Issue:
Pt 24
Pages:
5999-6005
Publication date:
2008-12-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Source identifiers:
20818
Language:
English
Keywords:
Pubs id:
pubs:20818
UUID:
uuid:58f0d046-99d9-4e7d-b0a4-b6541f1fc581
Local pid:
pubs:20818
Deposit date:
2012-12-19

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