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The increase in pulmonary arterial pressure caused by hypoxia depends on iron status.

Abstract:

Hypoxia is a major cause of pulmonary hypertension. Gene expression activated by the transcription factor hypoxia-inducible factor (HIF) is central to this process. The oxygen-sensing iron-dependent dioxygenase enzymes that regulate HIF are highly sensitive to varying iron availability. It is unknown whether iron similarly influences the pulmonary vasculature. This human physiology study aimed to determine whether varying iron availability affects pulmonary arterial pressure and the pulmonary...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Role:
Author
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Journal:
The Journal of physiology
Volume:
586
Issue:
Pt 24
Pages:
5999-6005
Publication date:
2008-12-05
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
URN:
uuid:58f0d046-99d9-4e7d-b0a4-b6541f1fc581
Source identifiers:
20818
Local pid:
pubs:20818

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