Journal article
Novel ketone diet enhances physical and cognitive performance
- Abstract:
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Ketone bodies are the most energy-efficient fuel and yield more ATP per mole of substrate than pyruvate and increase the free energy released from ATP hydrolysis. Elevation of circulating ketonesviahigh-fat, lowcarbohydrate diets has been used for the treatment of drug-refractory epilepsy and for neurodegenerative diseases, such as Parkinson’s disease. Ketones may also be beneficial for muscle and brain in times of stress, such as endurance exercise. The challenge has been to raise circulating ketone levels by using a palatable diet without altering lipid levels. We found that blood ketone levels canbe increased and cholesterol and triglycerides decreased by feeding rats a novel ketone ester diet: chow that is supplemented with (R)-3-hydroxybutyl (R)-3-hydroxybutyrate as 30% of calories. For 5 d, rats on the ketone diet ran 32% further on a treadmill than did control rats that ate an isocaloric diet that was supplemented with either corn starch or palm oil (P<0.05). Ketone-fed rats completed an 8-arm radial maze test 38% faster than did those on the other diets, making more correct decisions before making a mistake (P<0.05). Isolated, perfused hearts from rats that were fed the ketone diet had greater free energy available from ATP hydrolysis during increased work than did hearts from rats on the other diets as shown by using [31P]-NMR spectroscopy. The novel ketone diet, therefore, improved physical performance and cognitive function in rats, and its energy-sparing properties suggest that it may help to treat a range of human conditions with metabolic abnormalities.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Preview, Version of record, pdf, 1.5MB, Terms of use)
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- Publisher copy:
- 10.1096/fj.201600773R
Authors
- Funding agency for:
- Murray, A
- Grant:
- Academic Fellowship
- Publisher:
- Federation of American Societies for Experimental Biology
- Journal:
- FASEB Journal More from this journal
- Publication date:
- 2016-08-01
- Acceptance date:
- 2016-08-08
- DOI:
- ISSN:
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1530-6860
- Keywords:
- Pubs id:
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pubs:656072
- UUID:
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uuid:58ea8427-bb29-43fa-83f4-62ef132e1657
- Local pid:
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pubs:656072
- Source identifiers:
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656072
- Deposit date:
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2016-11-01
Terms of use
- Copyright holder:
- Clarke et al
- Copyright date:
- 2016
- Notes:
- © The Author(s) This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International (CC BY 4.0) (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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