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Does a local bystander effect necessitate a revision of TCP models that are based on observed clinical data?

Abstract:

It is shown that in order to derive a general model for tumor control probability (TCP) the two assumptions that on the microscopic level (1) clonogens are non-interacting and (2) clonogen killings are uncorrelated events are not necessary. In fact, these two assumptions can be replaced with two weaker ones that only ask that (a) therapy fractions are independent and non-overlapping and (b) the probability of an event only depends on the number of incidents happening during a time interval an...

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Publication status:
Published

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Publisher copy:
10.1080/02841860500468935

Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Bentzen, SM More by this author
Journal:
Acta oncologica (Stockholm, Sweden)
Volume:
45
Issue:
4
Pages:
406-411
Publication date:
2006
DOI:
EISSN:
1651-226X
ISSN:
0284-186X
URN:
uuid:58e0142a-c244-4bbe-b9c8-86c2abfc0998
Source identifiers:
228645
Local pid:
pubs:228645

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