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Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight

Abstract:

Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (PBonferroni < 1.06 x 10-7). In ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1038/s41467-019-09671-3

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Role:
Author
ORCID:
0000-0001-9850-5215
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Role:
Author
ORCID:
0000-0003-2906-4035
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Role:
Author
ORCID:
0000-0002-2279-4097
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
10
Pages:
Article: 1893
Publication date:
2019-04-23
Acceptance date:
2019-02-18
DOI:
EISSN:
2041-1723
Pubs id:
pubs:995727
URN:
uri:58a571a4-59c7-42f2-9365-5a71fa55d259
UUID:
uuid:58a571a4-59c7-42f2-9365-5a71fa55d259
Local pid:
pubs:995727

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