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Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation

Abstract:

Hyper-activation of extracellular signal-regulated kinase (ERK) 1/2 contributes to heart dysfunction in cardiomyopathy caused by mutations in the lamin A/C gene (LMNA cardiomyopathy). The mechanism of how this affects cardiac function is unknown. We show that active phosphorylated ERK1/2 directly binds to and catalyzes the phosphorylation of the actin depolymerizing factor cofilin-1 on Thr25. Cofilin-1 becomes active and disassembles actin filaments in a large array of cellular and animal mod...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/hmg/ddy215

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst Radiation Oncology
Role:
Author
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Publisher:
Oxford University Press Publisher's website
Journal:
Human Molecular Genetics Journal website
Volume:
27
Issue:
17
Pages:
3060-3078
Publication date:
2018-06-05
Acceptance date:
2018-05-30
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Pubs id:
pubs:924175
URN:
uri:5898ce31-e092-40d3-a05a-595ec32f99e3
UUID:
uuid:5898ce31-e092-40d3-a05a-595ec32f99e3
Local pid:
pubs:924175

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