Journal article
Electrocatalytic volleyball: rapid nanoconfined nicotinamide cycling for organic synthesis in electrode pores
- Abstract:
- In living cells, redox chains rely on nanoconfinement using tiny enclosures, such as the mitochondrial matrix or chloroplast stroma, to concentrate enzymes and limit distances that nicotinamide cofactors and other metabolites must diffuse. In a chemical analogue exploiting this principle, nicotinamide adenine dinucleotide phosphate (NADPH) and NADP+ are cycled rapidly between ferredoxin-NADP+ reductase and a second enzyme-the pairs being juxtaposed within the 5-100 nm scale pores of an indium tin oxide electrode. The resulting electrode material, denoted (FNR+E2)@ITO/support, can drive and exploit a potentially large number of enzyme-catalysed reactions.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 2.6MB, Terms of use)
-
- Publisher copy:
- 10.1002/anie.201814370
Authors
- Publisher:
- Wiley
- Journal:
- Angewandte Chemie International Edition More from this journal
- Volume:
- 58
- Issue:
- 15
- Pages:
- 4948-4952
- Publication date:
- 2019-02-14
- Acceptance date:
- 2019-01-11
- DOI:
- ISSN:
-
1433-7851, 1521-3773
- Pmid:
-
30633837
- Language:
-
English
- Keywords:
- Pubs id:
-
pubs:965973
- UUID:
-
uuid:5892c175-86c3-4e69-afa6-24cddd26843a
- Local pid:
-
pubs:965973
- Source identifiers:
-
965973
- Deposit date:
-
2019-03-06
- ARK identifier:
Terms of use
- Copyright holder:
- Megarity et al
- Copyright date:
- 2019
- Notes:
- © 2019 The Authors. Published by Wiley-VCH Verlag GmbH and Co. KGaA.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record