Transient Abnormal Myelopoiesis and AML in Down Syndrome: an Update.
Children with constitutional trisomy 21 (Down syndrome (DS)) have a unique predisposition to develop myeloid leukaemia of Down syndrome (ML-DS). This disorder is preceded by a transient neonatal preleukaemic syndrome, transient abnormal myelopoiesis (TAM). TAM and ML-DS are caused by co-operation between trisomy 21, which itself perturbs fetal haematopoiesis and acquired mutations in the key haematopoietic transcription factor gene GATA1. These mutations are found in almost one third of DS ne...Expand abstract
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- Peer reviewed
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- Springer Verlag Publisher's website
- Current Hematologic Malignancy Reports Journal website
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- Bhatnagar et al.
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- © The Author(s) 2016. This article is published with open access at Springerlink.com. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License.
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