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Transient Abnormal Myelopoiesis and AML in Down Syndrome: an Update.

Abstract:

Children with constitutional trisomy 21 (Down syndrome (DS)) have a unique predisposition to develop myeloid leukaemia of Down syndrome (ML-DS). This disorder is preceded by a transient neonatal preleukaemic syndrome, transient abnormal myelopoiesis (TAM). TAM and ML-DS are caused by co-operation between trisomy 21, which itself perturbs fetal haematopoiesis and acquired mutations in the key haematopoietic transcription factor gene GATA1. These mutations are found in almost one third of DS ne...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s11899-016-0338-x

Authors


Bhatnagar, N More by this author
Tunstall, O More by this author
More by this author
Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
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Department:
Oxford, MSD, Paediatrics
Publisher:
Springer Verlag Publisher's website
Journal:
Current Hematologic Malignancy Reports Journal website
Publication date:
2016-08-10
Acceptance date:
2016
DOI:
EISSN:
1558-822X
ISSN:
1558-8211
Pubs id:
pubs:638497
URN:
uri:588d0e62-babe-4b62-ae4e-a9a1b22e1e2f
UUID:
uuid:588d0e62-babe-4b62-ae4e-a9a1b22e1e2f
Local pid:
pubs:638497

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