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Myelin oligodendrocyte glycoprotein antibodies in neurological disease

Abstract:

Anti-myelin oligodendrocyte glycoprotein (MOG) antibodies (MOG-Abs) were first detected by immunoblot and enzyme-linked immunosorbent assay nearly 30 years ago, but their association with multiple sclerosis (MS) was not specific. Use of cell-based assays with native MOG as the substrate enabled identification of a group of MOG-Ab-positive patients with demyelinating phenotypes. Initially, MOG-Abs were reported in children with acute disseminated encephalomyelitis (ADEM). Further studies ident...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41582-018-0112-x

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Role:
Author
ORCID:
0000-0003-2817-1402
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Role:
Author
Publisher:
Nature Research Publisher's website
Journal:
Nature Reviews Neurology Journal website
Issue:
2
Publication date:
2018-12-17
Acceptance date:
2018-12-10
DOI:
EISSN:
1759-4766
ISSN:
1759-4758
Pubs id:
pubs:955171
URN:
uri:58588f1b-16a1-4fe9-944f-3eae20d8425f
UUID:
uuid:58588f1b-16a1-4fe9-944f-3eae20d8425f
Local pid:
pubs:955171
Language:
English
Keywords:

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