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SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells

Abstract:

During development, it is unclear if lineage-fated cells derive from multilineage-primed progenitors and whether active mechanisms operate to restrict cell fate. Here we investigate how mesoderm specifies into blood-fated cells. We document temporally restricted co-expression of blood (Scl/Tal1), cardiac (Mesp1) and paraxial (Tbx6) lineage-affiliated transcription factors in single cells, at the onset of blood specification, supporting the existence of common progenitors. At the same time-res...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1038/s41467-018-07787-6

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Subgroup:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
9
Pages:
Article: 5375
Publication date:
2018-12-18
Acceptance date:
2018-11-23
DOI:
ISSN:
2041-1723
Pubs id:
pubs:953303
URN:
uri:58554a4e-b0fd-4a96-85db-7b841dfca2ff
UUID:
uuid:58554a4e-b0fd-4a96-85db-7b841dfca2ff
Local pid:
pubs:953303
Language:
English

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