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Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease

Abstract:

Systematic epistasis analyses in multifactorial disorders are an important step to better characterize complex genetic risk structures. We conducted a hypothesis-free sex-stratified genome-wide screening for epistasis contributing to Alzheimer's disease (AD) susceptibility. We identified a statistical epistasis signal between the single nucleotide polymorphisms rs3733980 and rs7175766 that was associated with AD in males (genome-wide significant pBonferroni-corrected=0.0165). This signal poin...

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Publication status:
Published
Peer review status:
Peer reviewed

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Role:
Author
ORCID:
0000-0002-0283-2332
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Role:
Author
ORCID:
0000-0002-3562-1080
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Publisher:
Elsevier Publisher's website
Journal:
Neurobiology of Aging Journal website
Volume:
72
Pages:
188.e3-188.e12
Publication date:
2018-08-09
Acceptance date:
2018-08-01
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
Pmid:
30201328
Source identifiers:
920875

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