Journal article
Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease
- Abstract:
-
Systematic epistasis analyses in multifactorial disorders are an important step to better characterize complex genetic risk structures. We conducted a hypothesis-free sex-stratified genome-wide screening for epistasis contributing to Alzheimer's disease (AD) susceptibility. We identified a statistical epistasis signal between the single nucleotide polymorphisms rs3733980 and rs7175766 that was associated with AD in males (genome-wide significant pBonferroni-corrected=0.0165). This signal poin...
Expand abstract
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Publisher copy:
- 10.1016/j.neurobiolaging.2018.08.001
Why is the content I wish to access not available via ORA?
Bibliographic data (the information relating to research outputs) and full-text items (e.g. articles, theses, reports, etc.) arrive in ORA from several different sources. Unfortunately we are not able to make available the full-text for every research output.
Please contact the ORA team (
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
) if you have queries regarding unavailable content OR if you are aware of a full-text copy we can make available.
Content may be unavailable for the following four reasons
-
Version unsuitable
-
We have not obtained a suitable full-text for a given research output. See this page for more information.
-
Recently completed
-
Sometimes content is held in ORA but is unavailable for a fixed period of time to comply with the policies and wishes of rights holders.
-
Permissions
-
All content made available in ORA should comply with relevant rights, such as copyright. See this page for more information.
-
Clearance
-
Some thesis volumes scanned as part of the digitisation scheme funded by Dr Leonard Polonsky are currently unavailable due to sensitive material or uncleared third-party copyright content. We are attempting to contact authors whose theses are affected.
Alternative access to the full-text
You may be able to access the full-text directly from the publisher's website using the 'Publisher Copy' link in the 'Links & Downloads' box from a research output's ORA record page. This method may require an institutional or individual subscription to the journal/resource.
Authors
Funding
Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Neurobiology of Aging Journal website
- Volume:
- 72
- Pages:
- 188.e3-188.e12
- Publication date:
- 2018-08-09
- Acceptance date:
- 2018-08-01
- DOI:
- EISSN:
-
1558-1497
- ISSN:
-
0197-4580
- Pmid:
-
30201328
- Source identifiers:
-
920875
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:920875
- UUID:
-
uuid:58512c51-0f2d-4b74-a94a-8f2b4a243902
- Local pid:
- pubs:920875
- Deposit date:
- 2018-11-21
Terms of use
- Copyright holder:
- Elsevier Inc
- Copyright date:
- 2018
- Notes:
- © 2018 Elsevier Inc. All rights reserved.
If you are the owner of this record, you can report an update to it here: Report update to this record