- Abstract:
-
Systematic epistasis analyses in multifactorial disorders are an important step to better characterize complex genetic risk structures. We conducted a hypothesis-free sex-stratified genome-wide screening for epistasis contributing to Alzheimer's disease (AD) susceptibility. We identified a statistical epistasis signal between the single nucleotide polymorphisms rs3733980 and rs7175766 that was associated with AD in males (genome-wide significant pBonferroni-corrected=0.0165). This signal poin...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Publisher copy:
- 10.1016/j.neurobiolaging.2018.08.001
-
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- Publisher:
- Elsevier Publisher's website
- Journal:
- Neurobiology of Aging Journal website
- Volume:
- 72
- Pages:
- 188.e3-188.e12
- Publication date:
- 2018-08-09
- Acceptance date:
- 2018-08-01
- DOI:
- EISSN:
-
1558-1497
- ISSN:
-
0197-4580
- Pubs id:
-
pubs:920875
- URN:
-
uri:58512c51-0f2d-4b74-a94a-8f2b4a243902
- UUID:
-
uuid:58512c51-0f2d-4b74-a94a-8f2b4a243902
- Local pid:
- pubs:920875
- Language:
- English
- Keywords:
- Copyright holder:
- Elsevier Inc
- Copyright date:
- 2018
- Notes:
- © 2018 Elsevier Inc. All rights reserved.
Journal article
Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease
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