The Cranial Neural Crest in a Multiomics Era

Journal article

Neural crest ontogeny plays a prominent role in craniofacial development. In this Perspective article, we discuss recent advances to the understanding of mechanisms underlying the cranial neural crest gene regulatory network (cNC-GRN) stemming fromomics-based studies. We briefly summarize how parallel considerations of transcriptome, interactome, and epigenome data significantly elaborated the roles of key players derived from pre-omicsera studies. Furthermore, the growing cohort of cNC multiomics data revealed contribution of the non-coding genomic landscape. As technological improvements are constantly being developed, we reflect on key questions we are poised to address by taking advantage of the unique perspective a multiomics approach has to offer.

Authors: Chong-Morrison, V; Sauka-Spengler, T

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Frontiers Media
• Journal: Frontiers in Physiology
• Volume: 12
• Pages: 634440-634440
• Article number: 634440
• Publication date: 2021-03-01
• DOI: 10.3389/fphys.2021.634440
• EISSN: 1664-042X
• ISSN: 1664-042X
• Language: English
• Keywords: DNA methylation; Data science; Computational biology; Neural crest; Interactome; Neuroscience; Bioinformatics; Genetics; Genome; Transcriptome; Epigenome; Computer science; Gene; Genomics; Cranial neural crest; Biology