Liver X receptors downregulate 11beta-hydroxysteroid dehydrogenase type 1 expression and activity.

Journal article

11Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) converts inactive corticosteroids into biologically active corticosteroids, thereby regulating the local concentration of active glucocorticoids, such as cortisol. 11beta-HSD-1 is particularly expressed in adipocytes and liver and appears to be causally linked to the development of type 2 diabetes and the metabolic syndrome. Liver X receptor (LXR)-alpha and -beta are nuclear oxysterol receptors whose key role in lipid metabolic regulat...

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Authors: Stulnig, T; Oppermann, U; Steffensen, K; Schuster, G; Gustafsson, J

• Publication status: Published
• Journal: Diabetes
• Volume: 51
• Issue: 8
• Pages: 2426-2433
• Publication date: 2002-08-01
• DOI: 10.2337/diabetes.51.8.2426
• EISSN: 1939-327X
• ISSN: 0012-1797
• Language: English
• Keywords: RNA, Messenger; Hydroxysteroid Dehydrogenases; Sterol Regulatory Element Binding Protein 1; Cell Line; DNA Primers; Kinetics; Adipocytes; Gene Expression Regulation, Enzymologic; Transcription Factors; DNA-Binding Proteins; Mice; Receptors, Retinoic Acid; 3T3 Cells; Animals; Fibroblasts; Receptors, Thyroid Hormone; Receptors, Cytoplasmic and Nuclear; CCAAT-Enhancer-Binding Proteins; 11-beta-Hydroxysteroid Dehydrogenase Type 1; Time Factors; Orphan Nuclear Receptors