Journal article : Editorial
Disentangling contextual effects from musculoskeletal treatments
- Abstract:
- When a patient receives a treatment for a musculoskeletal pain condition, the outcome they experience (total effect) is made up of the specific treatment effect and non-specific effects that may include natural history, regression to the mean, and contextual effects 1. Understanding the specific effect of the treatment is important for research consumers; patients, clinicians and policy makers, as some treatments have harms or costs that could outweigh any positive specific effects. In this article we 1) discuss challenges in identifying and removing contextual effects in pragmatic trials, 2) introduce a way to isolate contextual effects of treatments using causal mediation analysis, and 3) highlight the importance of explicitly defining the contextual effect we want to estimate or control.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
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-
(Preview, Accepted manuscript, pdf, 101.5KB, Terms of use)
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- Publisher copy:
- 10.1016/j.joca.2020.12.011
Authors
- Publisher:
- Elsevier
- Journal:
- Osteoarthritis and Cartilage More from this journal
- Volume:
- 29
- Issue:
- 3
- Pages:
- 297-299
- Publication date:
- 2021-01-07
- Acceptance date:
- 2020-12-13
- DOI:
- ISSN:
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1063-4584
- Language:
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English
- Keywords:
- Subtype:
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Editorial
- Pubs id:
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1152130
- Local pid:
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pubs:1152130
- Deposit date:
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2021-01-05
- ARK identifier:
Terms of use
- Copyright holder:
- Osteoarthritis Research Society International
- Copyright date:
- 2020
- Rights statement:
- © 2021 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Elsevier at: https://doi.org/10.1016/j.joca.2020.12.011
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