Human glandular kallikrein 2 levels in serum for discrimination of pathologically organ-confined from locally-advanced prostate cancer in total PSA-levels below 10 ng/ml.

Journal article

BACKGROUND: We measured serum levels of human glandular kallikrein 2 (hK2) in patients treated with radical retropubic prostatectomy (rrP) for clinically localized prostate cancer (PCa) with a total PSA (tPSA)-level below 10 ng/ml to investigate whether hK2 can be applied to preoperatively distinguish organ-confined (pT2a/b) from nonorgan-confined (> or = pT3a)-PCa more accurately than total PSA. Further, we evaluated hK2, free- and tPSA-concentrations in all pathologic stages of PCa. METH...

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Authors: Haese, A; Graefen, M; Steuber, T; Becker, C; Pettersson, K

• Journal: Prostate
• Volume: 49
• Issue: 2
• Pages: 101-109
• Publication date: 2001-10-01
• DOI: 10.1002/pros.1123
• EISSN: 1097-0045
• ISSN: 0270-4137
• Language: English
• Keywords: Prostatic Neoplasms; Statistics, Nonparametric; Tissue Kallikreins; Neoplasm Staging; ROC Curve; Prostate-Specific Antigen; Cohort Studies; Male; Area Under Curve; Immunohistochemistry; Humans