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Exacerbation of acute traumatic brain injury by circulating extracellular vesicles

Abstract:

Inflammatory lesions in the brain activate a systemic acute phase response (APR), which is dependent on the release of extracellular vesicles (EVs) into the circulation. The resulting APR is responsible for regulating leukocyte mobilization and subsequent recruitment to the brain. Factors that either exacerbate or inhibit the APR will also exacerbate or inhibit CNS inflammation as a consequence, and have the potential to influence ongoing secondary damage. Here, we were interested to discover...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted Manuscript

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Publisher copy:
10.1089/neu.2017.5049

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
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Lundbeck Foundation More from this funder
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Grant:
Nathalie Rose Barr Award
Publisher:
Mary Ann Liebert Publisher's website
Journal:
Journal of Neurotrauma Journal website
Volume:
35
Issue:
4
Pages:
639-651
Publication date:
2018-01-11
DOI:
EISSN:
1557-9042
ISSN:
0897-7151
Pubs id:
pubs:801142
URN:
uri:57e96410-5fed-4540-ae1d-55ce6e1b6581
UUID:
uuid:57e96410-5fed-4540-ae1d-55ce6e1b6581
Local pid:
pubs:801142
Paper number:
4

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