Journal article icon

Journal article

Validation of the type 1 insulin-like growth factor receptor as a therapeutic target in renal cancer.

Abstract:

PURPOSE: Expression of the type 1 insulin-like growth factor receptor (IGF1R) confers adverse prognosis in clear cell renal cell cancer (CC-RCC). We recently showed that IGF1R expression is inhibited by the von Hippel-Lindau (VHL) tumor suppressor, and the IGF1R is up-regulated in CC-RCC, in which VHL is frequently inactivated. We tested the hypothesis that IGF1R up-regulation mediates resistance to cancer therapeutics, evaluating the effects of IGF1R depletion on sensitivity to cytotoxic dru...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Takiguchi, M More by this author
Expand authors...
Journal:
Molecular cancer therapeutics
Volume:
8
Issue:
6
Pages:
1448-1459
Publication date:
2009-06-05
DOI:
EISSN:
1538-8514
ISSN:
1535-7163
URN:
uuid:57cec8d7-0809-4780-8a81-38bd26a24653
Source identifiers:
22241
Local pid:
pubs:22241

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP