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A loss of host-derived MMP-7 promotes myeloma growth and osteolytic bone disease in vivo

Abstract:

Matrix metalloproteinases (MMPs) play a critical role in cancer pathogenesis, including tumor growth and osteolysis within the bone marrow microenvironment. However, the anti-tumor effects of MMPs are poorly understood, yet have significant implications for the therapeutic potential of targeting MMPs. Host derived MMP-7 has previously been shown to support the growth of bone metastatic breast and prostate cancer. In contrast and underscoring the complexity of MMP biology, here we identified a...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/s12943-017-0616-9

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
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Funding agency for:
Drake, M
Grant:
R01AR0207265
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Funding agency for:
Lynch, C
Grant:
R01CA143094
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Funding agency for:
Edwards, C
Grant:
R01 CA-137116
Publisher:
Springer Verlag Publisher's website
Journal:
Molecular Cancer Journal website
Volume:
16
Issue:
49
Pages:
1-8
Publication date:
2017-02-28
Acceptance date:
2017-02-20
DOI:
ISSN:
1476-4598
Source identifiers:
682336
Language:
English
Keywords:
Pubs id:
pubs:682336
UUID:
uuid:579942ed-ca0b-44a5-ac0a-48296ef4ea5f
Local pid:
pubs:682336
Deposit date:
2017-03-02

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