Journal article
A loss of host-derived MMP-7 promotes myeloma growth and osteolytic bone disease in vivo
- Abstract:
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Matrix metalloproteinases (MMPs) play a critical role in cancer pathogenesis, including tumor growth and osteolysis within the bone marrow microenvironment. However, the anti-tumor effects of MMPs are poorly understood, yet have significant implications for the therapeutic potential of targeting MMPs. Host derived MMP-7 has previously been shown to support the growth of bone metastatic breast and prostate cancer. In contrast and underscoring the complexity of MMP biology, here we identified a...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 1.2MB)
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- Publisher copy:
- 10.1186/s12943-017-0616-9
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Authors
Funding
+ The University
of Oxford Clarendon Fund Scholarship
More from this funder
Funding agency for:
Lwin, S
+ National
Institutes of Health
More from this funder
Funding agency for:
Drake, M
Grant:
R01AR0207265
+ National
Institutes of Health
More from this funder
Funding agency for:
Lynch, C
Grant:
R01CA143094
+ National
Institutes of Health
More from this funder
Funding agency for:
Edwards, C
Grant:
R01 CA-137116
Bibliographic Details
- Publisher:
- Springer Verlag Publisher's website
- Journal:
- Molecular Cancer Journal website
- Volume:
- 16
- Issue:
- 49
- Pages:
- 1-8
- Publication date:
- 2017-02-28
- Acceptance date:
- 2017-02-20
- DOI:
- ISSN:
-
1476-4598
- Source identifiers:
-
682336
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:682336
- UUID:
-
uuid:579942ed-ca0b-44a5-ac0a-48296ef4ea5f
- Local pid:
- pubs:682336
- Deposit date:
- 2017-03-02
Terms of use
- Copyright holder:
- © Lwin, et al 2017
- Copyright date:
- 2017
- Notes:
- © Lwin, et al. 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Licence:
- CC Attribution (CC BY)
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