Journal article
Evaluation of a rapid test for the diagnosis of cholera in the absence of a gold standard.
- Abstract:
- Early detection and confirmation of cholera outbreaks are crucial for rapid implementation of control measures. Because cholera frequently affects regions with limited laboratory resources, rapid diagnostic tests (RDT) designed for field conditions are important to enhance rapid response. Stool culture remains the "gold standard" for cholera diagnosis; however, its lack of sensitivity may lead to underestimation of test specificity. We evaluated the Crystal VC(r) immunochromatographic test (Span Diagnostics, India) for cholera diagnosis using a modified reference standard that combines culture-dependent and independent assays, or a Bayesian latent class model (LCM) analysis.
- Publication status:
- Published
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(Preview, pdf, 89.7KB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0037360
Authors
- Publisher:
- Public Library of Science
- Journal:
- PloS one More from this journal
- Volume:
- 7
- Issue:
- 5
- Article number:
- e37360
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
- Language:
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English
- Keywords:
- UUID:
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uuid:577e59cf-4b1a-4870-b830-cca36552d65b
- Local pid:
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pubs:334727
- Source identifiers:
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334727
- Deposit date:
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2012-12-19
Terms of use
- Copyright holder:
- Page et al
- Copyright date:
- 2012
- Notes:
- Copyright 2012 Page et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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