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A convenient catalytic asymmetric conjugate addition reaction to enones using alkylzirconium reagents

Abstract:
Alkylzirconium reagents undergo highly enantioselective copper-catalysed 1,4-addition reaction to cyclic enones. These reactions use alkylmetal species generated in situ from alkenes and the Schwartz reagent, and do not require premade organometallic reagents. The reactions have been performed on practical synthetic scales (2.5 mmol) and a scale-up to 10 mmol is demonstrated. The reactions proceed at room temperature, in a variety of solvents, and tolerate many functional groups. © Georg Thieme Verlag.
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1055/s-0033-1339485

Authors

More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author

Publisher:
Thieme Publishing
Journal:
Synthesis More from this journal
Volume:
45
Issue:
19
Pages:
2662-2668
Publication date:
2013-01-01
DOI:
EISSN:
1437-210X
ISSN:
0039-7881

Keywords:
Pubs id:
pubs:415733
UUID:
uuid:576055fb-8722-4755-9715-714f0aef5653
Local pid:
pubs:415733
Source identifiers:
415733
Deposit date:
2013-11-16

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