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Lithium vs. valproate vs. olanzapine vs. quetiapine as maintenance monotherapy for bipolar disorder: a population-based UK cohort study using electronic health records.

Abstract:

It is unclear which maintenance treatment for bipolar disorder is superior in clinical practice. Randomized controlled head-to-head trials of available drugs either do not exist or are inconclusive. We aimed to compare rates of monotherapy treatment failure in individuals prescribed lithium, valproate, olanzapine or quetiapine by a population-based cohort study using electronic health records. 5,089 patients with bipolar disorder were prescribed lithium (N=1,505), valproate (N=1,173) olanzapi...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1002/wps.20298

Authors


Marston, L More by this author
Walters, K More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Psychiatry
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Publisher:
Wiley Publisher's website
Journal:
World Psychiatry Journal website
Volume:
15
Issue:
1
Pages:
53-58
Publication date:
2016-02-01
DOI:
ISSN:
1723-8617
URN:
uuid:5756f42b-7968-45fd-8f53-fdad3120aa5f
Source identifiers:
601565
Local pid:
pubs:601565

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