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Long-term exposure of mouse pancreatic islets to oleate or palmitate results in reduced glucose-induced somatostatin and oversecretion of glucagon.

Abstract:

AIMS/HYPOTHESIS: Long-term exposure to NEFAs leads to inhibition of glucose-induced insulin secretion. We tested whether the release of somatostatin and glucagon, the two other major islet hormones, is also affected. METHODS: Mouse pancreatic islets were cultured for 72 h at 4.5 or 15 mmol/l glucose with or without 0.5 mmol/l oleate or palmitate. The release of glucagon and somatostatin during subsequent 1 h incubations at 1 or 20 mmol/l glucose as well as the islet content of the two hormon...

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Publication status:
Published

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Publisher copy:
10.1007/s00125-008-1082-0

Authors


Collins, SC More by this author
Eliasson, L More by this author
Olofsson, CS More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
Journal:
Diabetologia
Volume:
51
Issue:
9
Pages:
1689-1693
Publication date:
2008-09-05
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:5740dade-e477-458a-aeaa-3fab139af57c
Source identifiers:
29516
Local pid:
pubs:29516

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