Journal article
Cell sorting in an active nematic vertex model
- Abstract:
- We study a mixture of extensile and contractile cells using a vertex model extended to include active nematic stresses. The two cell populations phase separate over time. While phase separation strengthens monotonically with an increasing magnitude of contractile activity, the dependence on extensile activity is nonmonotonic, so that sufficiently high values reduce the extent of sorting. We interpret this by showing that extensile activity renders the system motile, enabling cells to undergo neighbor exchanges. Contractile cells that come into contact as a result are then more likely to stay connected due to an effective attraction arising from contractile activity.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 3.9MB, Terms of use)
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- Publisher copy:
- 10.1103/physrevlett.133.248401
Authors
+ UK Research and Innovation
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- Funder identifier:
- https://ror.org/001aqnf71
- Grant:
- EP/Y033981/1
- EP/W023946/1
- Publisher:
- American Physical Society
- Journal:
- Physical Review Letters More from this journal
- Volume:
- 133
- Issue:
- 24
- Article number:
- 248401
- Publication date:
- 2024-12-10
- Acceptance date:
- 2024-11-18
- DOI:
- EISSN:
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1079-7114
- ISSN:
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0031-9007
- Language:
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English
- Pubs id:
-
2070511
- Local pid:
-
pubs:2070511
- Deposit date:
-
2024-12-13
Terms of use
- Copyright holder:
- Rozman and Yeomans
- Copyright date:
- 2024
- Rights statement:
- ©2024 The Authors. Published by the American Physical Society under the terms of the Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.
- Licence:
- CC Attribution (CC BY)
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