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Journal article

Crystal structure of the C1 domain of cardiac myosin binding protein-C: implications for hypertrophic cardiomyopathy.

Abstract:

C-protein is a major component of skeletal and cardiac muscle thick filaments. Mutations in the gene encoding cardiac C-protein [cardiac myosin binding protein-C (cMyBP-C)] are one of the principal causes of hypertrophic cardiomyopathy. cMyBP-C is a string of globular domains including eight immunoglobulin-like and three fibronectin-like domains termed C0-C10. It binds to myosin and titin, and probably to actin, and may have both a structural and a regulatory role in muscle function. To help ...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2008.02.044

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Journal:
Journal of molecular biology
Volume:
378
Issue:
2
Pages:
387-397
Publication date:
2008-04-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:570c0173-ec42-4760-be7a-193593f8ee49
Source identifiers:
104896
Local pid:
pubs:104896

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