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Sustained MAPK/ERK activation in adult Schwann cells impairs nerve repair

Abstract:

The MAPK/ERK pathway has a critical role in PNS development. It is required for Schwann cell (SC) differentiation and myelination; sustained embryonic MAPK/ERK activation in SCs enhances myelin growth overcoming signals that normally end myelination. Excess activation of this pathway can be maladaptive as in adulthood acute strong activation of MAPK/ERK has been shown to cause SC dedifferentiation and demyelination. We used a mouse model (including male and female animals) in which gain of fu...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1523/JNEUROSCI.2255-17.2017

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Clinical Neurosciences
Birchmeier, C More by this author
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Publisher:
Society for Neuroscience Publisher's website
Journal:
Journal of Neuroscience Journal website
Volume:
38
Issue:
3
Pages:
679-690
Publication date:
2017-12-07
Acceptance date:
2017-10-19
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Pubs id:
pubs:737075
URN:
uri:56fc0aae-ac13-455f-96ee-0e54053d0ec3
UUID:
uuid:56fc0aae-ac13-455f-96ee-0e54053d0ec3
Local pid:
pubs:737075

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