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Journal article

Insights into the molecular mechanism for type 2 diabetes susceptibility at the KCNQ1 locus from temporal changes in imprinting status in human islets.

Abstract:

The molecular basis of type 2 diabetes predisposition at most established susceptibility loci remains poorly understood. KCNQ1 maps within the 11p15.5 imprinted domain, a region with an established role in congenital growth phenotypes. Variants intronic to KCNQ1 influence diabetes susceptibility when maternally inherited. By use of quantitative PCR and pyrosequencing of human adult islet and fetal pancreas samples, we investigated the imprinting status of regional transcripts and aimed to det...

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Publication status:
Published

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Publisher copy:
10.2337/db12-0819

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
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Journal:
Diabetes
Volume:
62
Issue:
3
Pages:
987-992
Publication date:
2013-03-05
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:56ef8eb1-45cb-46bd-88af-b5dfcb0d8e5b
Source identifiers:
358661
Local pid:
pubs:358661

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