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Journal article

G-quadruplex structures within the 3' UTR of LINE-1 elements stimulate retrotransposition.

Abstract:
Long Interspersed Nuclear Elements (LINEs) are ubiquitous transposable elements in higher eukaryotes that play a significant role in shaping genomes due to their abundance. Here, we report that guanine-rich sequences in the 3’-UTR of hominoid-specific LINE-1 elements are coupled with retrotransposon speciation and contribute to retrotransposition through the formation of G-quadruplex (G4) structures. We demonstrate that stabilising the G4 motif of a human-specific LINE-1 element with small-molecule ligands stimulates retrotransposition.
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nsmb.3367

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM, RDM Clinical Labaratory Sciences
Balasubramanian, S More by this author
Cancer Research UK More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Structural & Molecular Biology Journal website
Volume:
24
Issue:
3
Pages:
243-247
Publication date:
2017-01-05
Acceptance date:
2016-12-22
DOI:
EISSN:
1545-9993
ISSN:
1545-9985
Pubs id:
pubs:729654
URN:
uri:56eb4667-d0e6-4d6a-895d-9bb05b5bb60b
UUID:
uuid:56eb4667-d0e6-4d6a-895d-9bb05b5bb60b
Local pid:
pubs:729654

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