- Abstract:
- Long Interspersed Nuclear Elements (LINEs) are ubiquitous transposable elements in higher eukaryotes that play a significant role in shaping genomes due to their abundance. Here, we report that guanine-rich sequences in the 3’-UTR of hominoid-specific LINE-1 elements are coupled with retrotransposon speciation and contribute to retrotransposition through the formation of G-quadruplex (G4) structures. We demonstrate that stabilising the G4 motif of a human-specific LINE-1 element with small-molecule ligands stimulates retrotransposition.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
- Version:
- Accepted manuscript
- Files:
-
-
(pdf, 14.0mb)
-
- Publisher copy:
- 10.1038/nsmb.3367
-
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- Publisher:
- Nature Publishing Group Publisher's website
- Journal:
- Nature Structural & Molecular Biology Journal website
- Volume:
- 24
- Issue:
- 3
- Pages:
- 243-247
- Publication date:
- 2017-01-05
- Acceptance date:
- 2016-12-22
- DOI:
- EISSN:
-
1545-9993
- ISSN:
-
1545-9985
- Pubs id:
-
pubs:729654
- URN:
-
uri:56eb4667-d0e6-4d6a-895d-9bb05b5bb60b
- UUID:
-
uuid:56eb4667-d0e6-4d6a-895d-9bb05b5bb60b
- Local pid:
- pubs:729654
- Language:
- English
- Keywords:
- Copyright holder:
- Nature America, Inc.
- Copyright date:
- 2017
- Notes:
- © 2017 Nature America, Inc., part of Springer Nature. All rights reserved
Journal article
G-quadruplex structures within the 3' UTR of LINE-1 elements stimulate retrotransposition.
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Cancer Research UK
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